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MSU Capability Statement for the Avian Influenza (AI)Institutional Resources in AI Key institutional units at MSU with AI capability include: the nation’s premier Diagnostic Center for Population and Animal Health (DCPAH), the Center for Emerging Infectious Diseases (CEID), the College of Veterinary Medicine and the Department of Animal Science and the National Food Safety and Toxicology Center (NFSTC). The Diagnostics Center for Population and Animal Health (DCPAH) DCPAH is certified to conduct surveillance for avian influenza and a leader in establishing international OIE Quality Standard and Guidelines for Veterinary Laboratories: infectious diseases and the nation’s busiest diagnostic laboratory. The Michigan Legislature has provided strong state support of this important facility which represents the state's long-term commitment to public and animal health and safety. This 152,350 sq. ft. is the most comprehensive laboratory in North America, comprised of 65% laboratories with the remaining areas for administration/office space, the new complex features a Bio-Hazard Level-3 Containment Area, an incinerator facility, necropsy laboratories, necropsy support rooms and numerous, highly-specialized, state-of-the-art research/testing facilities. The Center for Emerging Infectious Diseases (CEID): On the campus of MSU, this multi-disciplinary center was established to build capacity in response to the nation’s growing concern with infectious diseases. Uniquely situated with established biosafety level 3 facilities at MSU, the Center faculty is able to provide appropriate containment conditions to perform advanced research and diagnostic capability to infectious pathogens under appropriate containment. The distinct advantage of this Center is real-time research that interfaces with animal/human and agriculture/human, microbial genomics and pathogen discovery. This Center coordinates services with key state and federal government agencies to help prevent and control emerging infectious The Center takes advantage of the breadth of expertise and facilities at MSU, in particular the Genomic Technology Support Facility, Center for Animal Functional Genomics, the Animal Health Diagnostic Laboratory, the Center for Remote Sensing and Geographic Information Science, the National Food Safety and Toxicology Center, and the on-campus expertise of faculty from a range of academic departments, units, and disciplines. College of Veterinary Medicine: Key departments in the College of Veterinary Medicine with expertise relevant to AI include:
The Department of Large Animal Clinical Sciences is a renowned scholarly community that includes a number of special features, including modern manure disposal facilities; 10 individual isolation stalls; on-site clinical pathology laboratories, and, most importantly, a specialized ventilation system that helps prevent the spread of infectious diseases. This new 42,000 sq. ft. facility is attached to the College of Vet Med and provides large animal clinical sciences for the public benefit with animal and human health clinical sciences with state-of-the-art expertise in diagnostic and therapeutic services relative to large animal clinical sciences.
This well established department is one of the oldest and largest in the US. Besides its many research activities, MSU professor Jerry Dodgson along with an international consortium of scientist published a paper identified the first bird and the first agricultural animal to have its genome sequenced. This chicken genome work is paving the way for better treatments or even new vaccines for the flu and other human ailments. The department is unique in that we serve three medical colleges (Osteopathic Medicine, Human Medicine, and Veterinary Medicine), the College of Natural Science, the Agricultural Experiment Station, and other units on campus.
The Department of Pathobiology and Diagnostic Investigation fosters excellence in Research, Teaching and Service. The main areas of research are microbiology and Immunology, Neurobiology, Pathobiology and Toxicology. The department fills a critical gap to unique research. Nasal toxicity of nanoparticles has not been previously examined - the center focus includes mechanisms involved in the pathogenesis of airway inhalation of airborne pollutants, 2) .
The hospital, equivalent to a 300-bed human hospital, provides high-quality service and patient care. The department has a solid reputation in orthopedic and thoracic surgery as well as anesthesiology. Current research in the department includes, but is not limited to, orthopedic research, molecular genetics, cardiomyoplasty, new anesthetic methods, and treatment and therapies for shock. The Laboratory for Comparative Orthopedic Research and the Laboratory for Molecular Medicine are special areas of emphasis in the department. Department of Animal Science (DAS): The Department of Animal Science has over 50 researchers and academic specialists with expertise in animal biology, management, including animal feeding, breeding, reproduction, and marketing. Poultry science is one of the Department’s areas of expertise. The poultry industry in Michigan is supported by the MSU College of Agriculture & Natural Resources Animal Science Department, the College of Veterinary Medicine Diagnostic Center and the MSU Extension Service. Over 4 million broilers are grown in Michigan represented by The Michigan Allied Poultry Industries Inc., public, elected officials and MSU. There is nearly universal membership in MAPI by commercial farm operations. The state is the headquarters for several large international poultry equipment suppliers – all working closely with MSU and MSU Extension services.
The Center’s resources and expertise in functional genomics provides national and international leadership in application of genomics technologies. This international resource for information on gene expression patterns and gene function has training capabilities in functional genomics, bioinformatics, and related concepts. Through participation in this Centers activities researchers have developed key functional genomics research tools that have enabled the profiling gene expression changes in bone marrow, blood, and tissue neutrophils as the cells' respond to stress and infection. Such novel discoveries would have significant relevance to agricultural and biomedical industries. National Food Safety and Toxicology Center (NFSTC) opened its doors in 1998, a 115,000-square-foot state-of-the-art research facility. The Center has built strong partnerships with public health officials, food producers and retailers, consumers, and other key stakeholders. The Center provides workshops and conferences in response to the needs of our stakeholders. On-going research at the center includes disciplines such as microbiology, toxicology; epidemiology, pre-harvest food safety, risk assessment, communication, and social science – delivering an increasing multidisciplinary approach to tackling major food safety issues. Relevant research programs include: 1) Development of Computer Models for Ranking the Public Health Impact of Foodborne Hazards and 2) Prioritizing Opportunities to Reduce Foodborne Disease. Together these programs have publications available to develop food safety systems 1) to prevent foodborne illness, (2) clarified responsibility and accountability for the effectiveness of interventions, (3) an integrated approach to food safety, and (4) risk-based allocation of government resources. The National Alliance for Food Safety (NAFS) is a consortium of 23 universities and the USDA Agricultural Research Service; MSU is a founding member and co-leader of NAFS. NAFS addresses global issues in food safety – international marketing of U.S. agricultural products and the safety of foods imported into the U.S. The National Alliance for Food Safety, has been headed by Dr. Lonnie King at Michigan State University coordinates the resources of these various institutions, created and posted a list of academic scientists who work in various areas of food safety. http://www.nafssfoodsafety.org/ Department of Food Science and Human Nutrition. The Food Science and Human Nutrition Department at MSU is one of the premier food science departments in the U.S., ranked among the top three U.S. programs in recent years. Teaching, research and extension programs cover the wide array of sciences (chemistry, microbiology, engineering, toxicology, nutrition, etc.) which are necessary for solving problems related to production, processing, distribution, evaluation, safety and utilization of food. USDA-ARS Avian Disease and Oncology Laboratory (ADOL) Research Laboratory. Conveniently located near the south side of campus this facility leads the nation’s research chicken genome mapping. The research at ADOL has established close cooperation among personnel of the Laboratory, the Michigan State Agricultural Experiment Station, and the teaching, research, and extension facilities of Michigan State University. The work at ASOL has a proven record of high quality research that has significantly reduced losses from diseases in chickens and turkeys. Disciplines represented by the laboratory scientists include genetics, virology, immunology, pathology, epidemiology, and molecular biology. The mission at the ADOL is to provide leadership in solving current and future problems in viral diseases of poultry using basic and applied multidisciplinary team approaches thereby benefiting the poultry industry and consumers. Key features of this research facility include containment buildings equipped to prevent spread of infection to the environment, high security isolators and filtration to contain high risk pathogens. Homeland Security Center for Food Protection Michigan State University is a key element in the nation’s Homeland Security Center for Food Protection and Defense. The Center addresses agro-security issues related to post-harvest food protection. MSU in partnerships with major food companies and universities (University of Wisconsin at Madison, North Dakota State University, Georgia Institute of Technology, Rutgers University, Harvard University, University of Tennessee, Cornell University, Purdue University and North Carolina State University). Michigan Health Preparedness - partner The Michigan Center for Public Health Preparedness (MI-CPHP) is part of a national network of centers established to support preparedness efforts of state and local health departments nationwide. The MI-CPHP is funded by the Centers for Disease Control and Prevention. MI-CPHP training products are competency-based, performance driven, targeted to the public health workforce, and designed to enhance individual and agency competency.
Training for Veterinary Infrastructure
3. Environmental and NRM Resources The Center for Integrative Toxicology, formerly known as the Institute for Environmental Toxicology, conducts research that highly integrates biomedical and remediation technology toward understanding and alleviating the adverse impacts on human health from exposure to chemicals commonly found in sites of hazardous waste. Chemical agents such as dioxins and polychlorinated biphenyls (PCBs) have been studied, as well as the toxicity of naturally occurring materials and pharmaceutical agents. Investigators seek to improve the assessment of human risk from PCBs and other toxic chemicals and develop strategies to counteract the toxic effects of the chemical once exposure has occurred. http://www.iet.msu.edu/ The GIS Spatial Data Resource Guide provides access to spatial data about Kellogg Biological Station and the surrounding area. Graphic images from aerial photography and satellite imagery are available to view and exhibit a general overview of the landscape while thematic maps identify the vegetation, soil structure and elevation in finite detail. Wildlife species information has also been recorded in this area and has been made available. Additional resources are available from Michigan Resource Information Systems, Great Lakes Environmental Atlas, United States Geological Survey and the U.S. EPA Center for Environmental Statistics. This site aims to document long-term ecological research in row-crop agriculture. http://lternt2.kbs.msu.edu/GIS/index.html 4. Expertise Relevant to Avian Influenza at MSU For several decades Michigan State University faculty have conducted research from health of fowl to biosecurity; from controlling infectious disease in animals to communicating risks to humans; from how human medicine merges with veterinary medicine, and even with wildlife biology. In addition, Michigan State University has an active poultry extension program where their faculty provides expertise in disease and disease control and prevention directly to the Michigan commercial poultry industry. Michigan serves as a model for other states in its coordinated efforts of disease control which involves Michigan State University’s poultry faculty in the Department of Animal Science and the College of Veterinary Medicine Michigan State, the State Veterinarian’s personnel of the Michigan Department of Agriculture, Michigan’s Federal Veterinarian personnel and the Michigan Allied Poultry Industry, Inc. (the agency that represents Michigan’s commercial poultry industry. |
